Skip to content
[P]pubcas
Independent chemical reference Compare
Home/Chemicals/100324-81-0
Chemical substance record

(R)-lisofylline

100324-81-0C13H20N4O3280.328 g/mol
Organic/Inorganic Small MoleculeChEBI source record

A 1-(5-hydroxyhexyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione that has (R)-configuration. A synthetic small molecule which was under development for the treatment of type 1 diabetes mellitus. — ChEBI

Safety references

Safety documents & references

Supplier matching matters

Find the safety document for your specific supplier, product number and grade.

Find a product-specific SDS

Search SDS PDFs Sigma-Aldrich Thermo Fisher

Safety guides and government classification records are not a manufacturer’s SDS. Match supplier, product number, concentration, physical form, region and revision before using a document.

Identity & molecular properties

Source-linked values
CAS number100324-81-0ChEBI ↗
Molecular formulaC13H20N4O3ChEBI ↗
Molar mass280.328 g/molChEBI ↗
Monoisotopic mass280.15354 DaChEBI ↗
Formal charge0ChEBI ↗
ChEBI identifierCHEBI:143527ChEBI ↗

Cross-source molecular data

PubChem
Molar mass280.32 g/molPubChem ↗
Exact mass280.15354051 DaPubChem ↗
Computed XLogP0.7PubChem ↗
Topological polar surface area (Ų)78.7PubChem ↗
H-bond donors1PubChem ↗
H-bond acceptors4PubChem ↗
Rotatable bonds5PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

Copy any identifier
(R)-lisofylline
1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione
NSMXQKNUPPXBRG-SECBINFHSA-N
C[C@@H](O)CCCCn1c(=O)c2c(ncn2C)n(C)c1=O
InChI=1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3/t9-/m1/s1

Names & synonyms

1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dionelisofilinalisofyllinelisofyllinumProTec

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology
1-(5-hydroxyhexyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dioneChEBI parent class · 143565 ↗
alcoholorganic heterocyclic compoundorganic molecular entity

Roles recorded in ChEBI

hypoglycemic agentimmunomodulatoranti-inflammatory agent

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass
Equivalent amount
0.00356725 mol

Uses 280.328 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions
C
Carbon · 13 atoms
55.70%
N
Nitrogen · 4 atoms
19.99%
O
Oxygen · 3 atoms
17.12%
H
Hydrogen · 20 atoms
7.19%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations
Effects of lisofylline on hyperoxia-induced lung injury. ↗The American journal of physiology · 1999 May · PMID 10330034
Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome. ↗Critical care medicine · 2002 Jan · PMID 11902249
WO2009099582 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.
Search PubMed Google Scholar

Sources & record history

Checked 27 Sep 2026
EMBL-EBI ChEBI · CHEBI:143527

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

NCBI PubChem · CID 501254 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

How this record was assembledSuggest a correction