Home/Chemicals/19982-08-2

Chemical substance record

Memantine

19982-08-2C₁₂H₂₁N179.307 g/mol

Organic/Inorganic Small MoleculeChEBI source record

A primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels. — ChEBI

Safety references

Safety documents & references

Supplier matching matters

Find the safety document for your specific supplier, product number and grade.

Find a product-specific SDS

Search SDS PDFs Sigma-Aldrich Thermo Fisher

Safety guides and government classification records are not a manufacturer’s SDS. Match supplier, product number, concentration, physical form, region and revision before using a document.

Identity & molecular properties

Source-linked values

CAS number	19982-08-2	ChEBI ↗
Molecular formula	C₁₂H₂₁N	ChEBI ↗
Molar mass	179.307 g/mol	ChEBI ↗
Monoisotopic mass	179.1674 Da	ChEBI ↗
Formal charge	0	ChEBI ↗
ChEBI identifier	CHEBI:64312	ChEBI ↗

Cross-source molecular data

PubChem

Molar mass	179.30 g/mol	PubChem ↗
Exact mass	179.167399674 Da	PubChem ↗
Computed XLogP	3.3	PubChem ↗
Topological polar surface area (Å²)	26	PubChem ↗
H-bond donors	1	PubChem ↗
H-bond acceptors	1	PubChem ↗
Rotatable bonds	0	PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

Copy any identifier

Source preferred name

memantine

IUPAC name

3,5-dimethyladamantan-1-amine

InChIKey

BUGYDGFZZOZRHP-UHFFFAOYSA-N

SMILES

CC12CC3CC(C)(C1)CC(N)(C3)C2

InChI

InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3

Names & synonyms

3,5-dimethyladamantan-1-aminememantinamemantinum

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

primary aliphatic amineChEBI parent class · 17062 ↗adamantanesChEBI parent class · 51339 ↗

amine organic molecular entity

Roles recorded in ChEBI

antidepressantanxiolytic drugantipsychotic agentanalgesicantineoplastic agentimmunosuppressive agentantiglaucoma drugantiparkinson drugdopaminergic agentNMDA receptor antagonist

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass

Amount

Input unit

Equivalent amount

0.00557703 mol

Uses 179.307 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions

C

Carbon · 12 atoms

80.38%

H

Hydrogen · 21 atoms

11.81%

N

Nitrogen · 1 atom

7.81%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations

Spotlight on memantine in moderate to severe Alzheimer's disease. ↗Drugs & aging · 2010 Feb 1 · PMID 20104942

Administration of memantine and imipramine alters mitochondrial respiratory chain and creatine kinase activities in rat brain. ↗Journal of neural transmission (Vienna, Austria : 1996) · 2012 Apr · PMID 21953515

US2011282100 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

Search PubMed Google Scholar

Sources & record history

Checked 27 Sep 2026

Identity, formula, mass, synonyms & ontologyEMBL-EBI ChEBI · CHEBI:64312

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

Additional molecular descriptorsNCBI PubChem · CID 4054 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

How this record was assembled Suggest a correction