Chemical substance record

4-hydroxy-TEMPO

2226-96-2C₉H₁₈NO₂172.248 g/mol

Organic/Inorganic Small MoleculeChEBI source record

A member of the class of aminoxyls that is TEMPO carrying a hydroxy substituent at position 4. It is a radical scavenger which exhibits anti-inflammatory and analgesic properties. — ChEBI

Safety references

Safety documents & references

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Identity & molecular properties

Source-linked values

CAS number	2226-96-2	ChEBI ↗
Molecular formula	C₉H₁₈NO₂	ChEBI ↗
Molar mass	172.248 g/mol	ChEBI ↗
Monoisotopic mass	172.13375 Da	ChEBI ↗
Formal charge	0	ChEBI ↗
ChEBI identifier	CHEBI:180664	ChEBI ↗

Names & structural identifiers

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Source preferred name

4-hydroxy-TEMPO

IUPAC name

(4-hydroxy-2,2,6,6-tetramethylpiperidin-1-yl)oxidanyl

InChIKey

UZFMOKQJFYMBGY-UHFFFAOYSA-N

SMILES

CC1(C)CC(O)CC(C)(C)N1[O]

InChI

InChI=1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3

Names & synonyms

(4-hydroxy-2,2,6,6-tetramethylpiperidin-1-yl)oxidanyl

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

aminoxylsChEBI parent class · 39477 ↗hydroxypiperidineChEBI parent class · 48590 ↗

organic heterocyclic compound organic molecular entity

Roles recorded in ChEBI

antiviral agentcatalystcardiovascular drugantineoplastic agentradical scavengerhepatoprotective agentneuroprotective agentanti-inflammatory agentapoptosis inducernephroprotective agent

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass

Amount

Input unit

Equivalent amount

0.00580558 mol

Uses 172.248 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions

C

Carbon · 9 atoms

62.76%

O

Oxygen · 2 atoms

18.58%

H

Hydrogen · 18 atoms

10.53%

N

Nitrogen · 1 atom

8.13%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations

Neuroprotective effect of tempol (4 hydroxy-tempo) on neuronal death induced by sciatic nerve transection in neonatal rats. ↗Brain research bulletin · 2014 Jul · PMID 24769526

Studies on bio-antioxidants--micellar effects on the reduction of nitroxides by vitamin C. ↗Science in China. Series B, Chemistry, life sciences & earth sciences · 1989 Aug · PMID 2610866

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Sources & record history

Checked 27 Sep 2026

Identity, formula, mass, synonyms & ontologyEMBL-EBI ChEBI · CHEBI:180664

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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