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Chemical substance record

Mianserin

24219-97-4C18H20N2264.372 g/mol
Organic/Inorganic Small MoleculeChEBI source record

A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere. — ChEBI

Safety references

Safety documents & references

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Identity & molecular properties

Source-linked values
CAS number24219-97-4ChEBI ↗
Molecular formulaC18H20N2ChEBI ↗
Molar mass264.372 g/molChEBI ↗
Monoisotopic mass264.16265 DaChEBI ↗
Formal charge0ChEBI ↗
ChEBI identifierCHEBI:51137ChEBI ↗

Cross-source molecular data

PubChem
Molar mass264.4 g/molPubChem ↗
Exact mass264.162648646 DaPubChem ↗
Computed XLogP3.4PubChem ↗
Topological polar surface area (Ų)6.5PubChem ↗
H-bond donors0PubChem ↗
H-bond acceptors2PubChem ↗
Rotatable bonds0PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

Copy any identifier
mianserin
2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine
UEQUQVLFIPOEMF-UHFFFAOYSA-N
CN1CCN2c3ccccc3Cc3ccccc3C2C1
InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3

Names & synonyms

2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepinemianserinamianserinemianserinum

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology
dibenzoazepineChEBI parent class · 47804 ↗
organic heterocyclic compoundorganic molecular entity

Roles recorded in ChEBI

geroprotectorantidepressantanxiolytic drugantipsychotic agentadrenergic uptake inhibitorhistamine agonistsedativealpha-adrenergic antagonistH1-receptor antagonistserotonergic antagonist

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass
Equivalent amount
0.00378255 mol

Uses 264.372 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions
C
Carbon · 18 atoms
81.78%
N
Nitrogen · 2 atoms
10.60%
H
Hydrogen · 20 atoms
7.63%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations
An antidepressant that extends lifespan in adult Caenorhabditis elegans. ↗Nature · 2007 Nov 22 · PMID 18033297
Effects of diverse psychopharmacological substances on the activity of brain prolyl oligopeptidase. ↗Basic & clinical pharmacology & toxicology · 2011 Jan · PMID 20825390
NL6603256 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.
US3534041 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.
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Sources & record history

Checked 27 Sep 2026
EMBL-EBI ChEBI · CHEBI:51137

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

NCBI PubChem · CID 4184 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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