Chemical substance record

Glipizide

29094-61-9C₂₁H₂₇N₅O₄S445.545 g/mol

Organic/Inorganic Small MoleculeChEBI source record

An N-sulfonylurea that is glyburide in which the (5-chloro-2-methoxybenzoyl group is replaced by a (5-methylpyrazin-2-yl)carbonyl group. An oral hypoglycemic agent, it is used in the treatment of type 2 diabetes mellitus. — ChEBI

Safety references

Safety documents & references

Supplier matching matters

Find the safety document for your specific supplier, product number and grade.

Find a product-specific SDS

Search SDS PDFs Sigma-Aldrich Thermo Fisher

Safety guides and government classification records are not a manufacturer’s SDS. Match supplier, product number, concentration, physical form, region and revision before using a document.

Identity & molecular properties

Source-linked values

CAS number	29094-61-9	ChEBI ↗
Molecular formula	C₂₁H₂₇N₅O₄S	ChEBI ↗
Molar mass	445.545 g/mol	ChEBI ↗
Monoisotopic mass	445.17838 Da	ChEBI ↗
Formal charge	0	ChEBI ↗
ChEBI identifier	CHEBI:5384	ChEBI ↗

Cross-source molecular data

PubChem

Molar mass	445.5 g/mol	PubChem ↗
Exact mass	445.17837553 Da	PubChem ↗
Computed XLogP	1.9	PubChem ↗
Topological polar surface area (Å²)	139	PubChem ↗
H-bond donors	3	PubChem ↗
H-bond acceptors	6	PubChem ↗
Rotatable bonds	7	PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

Copy any identifier

Source preferred name

glipizide

IUPAC name

N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-5-methylpyrazine-2-carboxamide

InChIKey

ZJJXGWJIGJFDTL-UHFFFAOYSA-N

SMILES

Cc1cnc(C(=O)NCCc2ccc(S(=O)(=O)NC(=O)NC3CCCCC3)cc2)cn1

InChI

InChI=1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)

Names & synonyms

AldiabDigrinDipazideGlibeneseGlibetinGlicanGlidiabGlipidglipizidaglipizidumGluco-RiteGlucolip

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

monocarboxylic acid amideChEBI parent class · 29347 ↗pyrazinesChEBI parent class · 38314 ↗aromatic amideChEBI parent class · 62733 ↗N-sulfonylureaChEBI parent class · 76983 ↗

organosulfur compound organic heterocyclic compound organic molecular entity

Roles recorded in ChEBI

antiatherosclerotic agenthypoglycemic agentantineoplastic agentEC 2.7.1.33 (pantothenate kinase) inhibitorinsulin secretagogue

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass

Amount

Input unit

Equivalent amount

0.00224444 mol

Uses 445.545 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions

C

Carbon · 21 atoms

56.61%

N

Nitrogen · 5 atoms

15.72%

O

Oxygen · 4 atoms

14.36%

S

Sulfur · 1 atom

7.20%

H

Hydrogen · 27 atoms

6.11%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations

Glipizide. A review of the pharmacoeconomic implications of the extended-release formulation in type 2 diabetes mellitus. ↗PharmacoEconomics · 2000 Sep · PMID 11147395

Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain. ↗Chemistry & biology · 2010 Aug 27 · PMID 20797618

DE2012138 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

US3669966 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

Search PubMed Google Scholar

Sources & record history

Checked 27 Sep 2026

Identity, formula, mass, synonyms & ontologyEMBL-EBI ChEBI · CHEBI:5384

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

Additional molecular descriptorsNCBI PubChem · CID 3478 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

How this record was assembled Suggest a correction