Chemical substance record

Triamterene

396-01-0C₁₂H₁₁N₇253.269 g/mol

Organic/Inorganic Small MoleculeChEBI source record

Pteridine substituted at positions 2, 4 and 7 with amino groups and at position 6 with a phenyl group. A sodium channel blocker, it is used as a diuretic in the treatment of hypertension and oedema. — ChEBI

Safety references

Safety documents & references

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Identity & molecular properties

Source-linked values

CAS number	396-01-0	ChEBI ↗
Molecular formula	C₁₂H₁₁N₇	ChEBI ↗
Molar mass	253.269 g/mol	ChEBI ↗
Monoisotopic mass	253.10759 Da	ChEBI ↗
Formal charge	0	ChEBI ↗
ChEBI identifier	CHEBI:9671	ChEBI ↗

Cross-source molecular data

PubChem

Molar mass	253.26 g/mol	PubChem ↗
Exact mass	253.10759338 Da	PubChem ↗
Computed XLogP	1	PubChem ↗
Topological polar surface area (Å²)	130	PubChem ↗
H-bond donors	3	PubChem ↗
H-bond acceptors	7	PubChem ↗
Rotatable bonds	1	PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

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Source preferred name

triamterene

IUPAC name

6-phenylpteridine-2,4,7-triamine

InChIKey

FNYLWPVRPXGIIP-UHFFFAOYSA-N

SMILES

Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1

InChI

InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)

Names & synonyms

6-phenylpteridine-2,4,7-triaminetriamterenatriamterenum

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

pteridinesChEBI parent class · 26373 ↗

organic heterocyclic compound organic molecular entity

Roles recorded in ChEBI

antiatherosclerotic agentdiuretichypoglycemic agentcardiovascular drugantihypertensive agentsodium channel blockerhepatoprotective agent

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass

Amount

Input unit

Equivalent amount

0.00394837 mol

Uses 253.269 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions

C

Carbon · 12 atoms

56.91%

N

Nitrogen · 7 atoms

38.71%

H

Hydrogen · 11 atoms

4.38%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations

Triamterene Enhances the Blood Pressure Lowering Effect of Hydrochlorothiazide in Patients with Hypertension. ↗Journal of general internal medicine · 2016 Jan · PMID 26194642

Triamterene in the Treatment of Hypertension: More Than Just Potassium Sparing? ↗Journal of general internal medicine · 2016 Jan · PMID 26385116

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Sources & record history

Checked 27 Sep 2026

Identity, formula, mass, synonyms & ontologyEMBL-EBI ChEBI · CHEBI:9671

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

Additional molecular descriptorsNCBI PubChem · CID 5546 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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