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Chemical substance record

Phenobarbital

50-06-6C12H12N2O3232.239 g/mol

A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups. — ChEBI

Safety references

Safety documents & references

1 indexed references
JP · NITE

Government GHS classification

R06-C-001-JNIOSH · FY2024

View classification

Find a product-specific SDS

Safety guides and government classification records are not a manufacturer’s SDS. Match supplier, product number, concentration, physical form, region and revision before using a document.

Identity & molecular properties

Source-linked values
CAS number50-06-6ChEBI ↗
Molecular formulaC12H12N2O3ChEBI ↗
Molar mass232.239 g/molChEBI ↗
Monoisotopic mass232.08479 DaChEBI ↗
Formal charge0ChEBI ↗
ChEBI identifierCHEBI:8069ChEBI ↗

Cross-source molecular data

PubChem
Molar mass232.23 g/molPubChem ↗
Exact mass232.08479225 DaPubChem ↗
Computed XLogP1.5PubChem ↗
Topological polar surface area (Ų)75.3PubChem ↗
H-bond donors2PubChem ↗
H-bond acceptors3PubChem ↗
Rotatable bonds2PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

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phenobarbital
5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione
DDBREPKUVSBGFI-UHFFFAOYSA-N
CCC1(c2ccccc2)C(=O)NC(=O)NC1=O
InChI=1S/C12H12N2O3/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16/h3-7H,2H2,1H3,(H2,13,14,15,16,17)

Names & synonyms

5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trioneLuminal

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

Roles recorded in ChEBI

antidepressantanxiolytic drugantipsychotic agentantineoplastic agentanticonvulsantsedativeexcitatory amino acid antagonistdrug allergen

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Safety classification · Japan

NITE / Japanese government
Japan · FY2024 source classification
Phenobarbital · R06-C-001-JNIOSH
EndpointReported classification
CarcinogenicityCategory 1B

Selected source-reported endpoints. Other endpoints, rationales and conditions remain in the original classification. Missing or unlisted information does not mean non-hazardous. This is not a global classification or transport decision.

Read the original NITE classification

Mass ↔ amount of substance

Calculated from sourced mass
Equivalent amount
0.00430591 mol

Uses 232.239 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions
C
Carbon · 12 atoms
62.06%
O
Oxygen · 3 atoms
20.67%
N
Nitrogen · 2 atoms
12.06%
H
Hydrogen · 12 atoms
5.21%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations
Prediction of drug solubility from Monte Carlo simulations. ↗Bioorganic & medicinal chemistry letters · 2000 Jun 5 · PMID 10866370
QSAR model for drug human oral bioavailability. ↗Journal of medicinal chemistry · 2000 Jun 29 · PMID 10891117
US1025872 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

Sources & record history

Checked 27 Sep 2026
EMBL-EBI ChEBI · CHEBI:8069

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

NCBI PubChem · CID 4763 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.