Chemical substance record

Trolox

53188-07-1C₁₄H₁₈O₄250.294 g/mol

Organic/Inorganic Small MoleculeChEBI source record

A chromanol that is 6-hydroxychromane which is substituted by a carboxy group at position 2 and by methyl groups at positions 2, 5, 7, and 8. A cell-permeable, water-soluble analogue of vitamin E, it is used as a standard for measuring the antioxidant capacity of complex mixtures. — ChEBI

Safety references

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Identity & molecular properties

Source-linked values

CAS number	53188-07-1	ChEBI ↗
Molecular formula	C₁₄H₁₈O₄	ChEBI ↗
Molar mass	250.294 g/mol	ChEBI ↗
Monoisotopic mass	250.12051 Da	ChEBI ↗
Formal charge	0	ChEBI ↗
ChEBI identifier	CHEBI:82625	ChEBI ↗

Cross-source molecular data

PubChem

Molar mass	250.29 g/mol	PubChem ↗
Exact mass	250.12050905 Da	PubChem ↗
Computed XLogP	2.8	PubChem ↗
Topological polar surface area (Å²)	66.8	PubChem ↗
H-bond donors	2	PubChem ↗
H-bond acceptors	4	PubChem ↗
Rotatable bonds	1	PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

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Source preferred name

Trolox

IUPAC name

6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylic acid

InChIKey

GLEVLJDDWXEYCO-UHFFFAOYSA-N

SMILES

Cc1c(C)c2c(c(C)c1O)CCC(C)(C(=O)O)O2

InChI

InChI=1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)

Names & synonyms

6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylic acidTrolox C

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

chromanolChEBI parent class · 23229 ↗monocarboxylic acidChEBI parent class · 25384 ↗phenolsChEBI parent class · 33853 ↗

carboxylic acid phenols organic heterocyclic compound organic molecular entity

Roles recorded in ChEBI

ferroptosis inhibitorantioxidantradical scavengerneuroprotective agentWnt signalling inhibitor

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass

Amount

Input unit

Equivalent amount

0.0039953 mol

Uses 250.294 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions

C

Carbon · 14 atoms

67.18%

O

Oxygen · 4 atoms

25.57%

H

Hydrogen · 18 atoms

7.25%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations

Trolox C, a lipid-soluble membrane protective agent, attenuates myocardial injury from ischemia and reperfusion. ↗Free radical biology & medicine · 1992 Dec · PMID 1459482

Neuroprotective effects of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox), an antioxidant in middle cerebral artery occlusion induced focal cerebral ischemia in rats. ↗Neurological research · 2007 Apr · PMID 17509231

JP2006306808 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

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Sources & record history

Checked 27 Sep 2026

Identity, formula, mass, synonyms & ontologyEMBL-EBI ChEBI · CHEBI:82625

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

Additional molecular descriptorsNCBI PubChem · CID 40634 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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