Chemical substance record

Cyclizine

82-92-8C₁₈H₂₂N₂266.381 g/mol

Organic/Inorganic Small MoleculeChEBI source record

An N-alkylpiperazine in which one nitrogen of the piperazine ring is substituted by a methyl group, while the other is substituted by a diphenylmethyl group. — ChEBI

Safety references

Safety documents & references

Supplier matching matters

Find the safety document for your specific supplier, product number and grade.

Find a product-specific SDS

Search SDS PDFs Sigma-Aldrich Thermo Fisher

Safety guides and government classification records are not a manufacturer’s SDS. Match supplier, product number, concentration, physical form, region and revision before using a document.

Identity & molecular properties

Source-linked values

CAS number	82-92-8	ChEBI ↗
Molecular formula	C₁₈H₂₂N₂	ChEBI ↗
Molar mass	266.381 g/mol	ChEBI ↗
Monoisotopic mass	266.1783 Da	ChEBI ↗
Formal charge	0	ChEBI ↗
ChEBI identifier	CHEBI:3994	ChEBI ↗

Cross-source molecular data

PubChem

Molar mass	266.4 g/mol	PubChem ↗
Exact mass	266.178298710 Da	PubChem ↗
Computed XLogP	3.6	PubChem ↗
Topological polar surface area (Å²)	6.5	PubChem ↗
H-bond donors	0	PubChem ↗
H-bond acceptors	2	PubChem ↗
Rotatable bonds	3	PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

Copy any identifier

Source preferred name

cyclizine

IUPAC name

1-(diphenylmethyl)-4-methylpiperazine

InChIKey

UVKZSORBKUEBAZ-UHFFFAOYSA-N

SMILES

CN1CCN(C(c2ccccc2)c2ccccc2)CC1

InChI

InChI=1S/C18H22N2/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18H,12-15H2,1H3

Names & synonyms

1-(diphenylmethyl)-4-methylpiperazineciclizinacyclizinum

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

N-alkylpiperazineChEBI parent class · 46845 ↗

organic heterocyclic compound organic molecular entity

Roles recorded in ChEBI

central nervous system depressantlocal anaestheticH1-receptor antagonistcholinergic antagonistantiemetic

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass

Amount

Input unit

Equivalent amount

0.00375402 mol

Uses 266.381 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions

C

Carbon · 18 atoms

81.16%

N

Nitrogen · 2 atoms

10.52%

H

Hydrogen · 22 atoms

8.32%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations

The pharmacokinetics and pharmacogenetics of the antiemetic cyclizine in palliative care patients. ↗Journal of pain and symptom management · 2012 Mar · PMID 22209223

Post-operative cyclizine misuse. ↗Scottish medical journal · 2013 Nov · PMID 24215049

US2630435 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

Search PubMed Google Scholar

Sources & record history

Checked 27 Sep 2026

Identity, formula, mass, synonyms & ontologyEMBL-EBI ChEBI · CHEBI:3994

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

Additional molecular descriptorsNCBI PubChem · CID 6726 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

How this record was assembled Suggest a correction