Midafotel
A member of the class of piperazines that is piperazine substituted by a carboxy group at position 2R and a (1E)-1-phosphonoprop-1-en-3-yl group at position 4. It is an antagonist of N-methyl-D-aspartate receptors (NMDARs) and was in clinical development by Novartis for the treatment of cognition disorders and brain injuries (now discontinued). — ChEBI
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Identity & molecular properties
Source-linked values| CAS number | 117414-74-1 | ChEBI ↗ |
| Molecular formula | C8H15N2O5P | ChEBI ↗ |
| Molar mass | 250.191 g/mol | ChEBI ↗ |
| Monoisotopic mass | 250.07186 Da | ChEBI ↗ |
| Formal charge | 0 | ChEBI ↗ |
| ChEBI identifier | CHEBI:180900 | ChEBI ↗ |
Cross-source molecular data
PubChem| Molar mass | 250.19 g/mol | PubChem ↗ |
| Exact mass | 250.07185858 Da | PubChem ↗ |
| Computed XLogP | -7 | PubChem ↗ |
| Topological polar surface area (Ų) | 110 | PubChem ↗ |
| H-bond donors | 4 | PubChem ↗ |
| H-bond acceptors | 7 | PubChem ↗ |
| Rotatable bonds | 4 | PubChem ↗ |
PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.
Names & structural identifiers
Copy any identifiermidafotel(2R)-4-[(2E)-3-phosphonoprop-2-en-1-yl]piperazine-2-carboxylic acidVZXMZMJSGLFKQI-ABVWVHJUSA-NO=C(O)[C@H]1CN(C/C=C/P(=O)(O)O)CCN1InChI=1S/C8H15N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h1,5,7,9H,2-4,6H2,(H,11,12)(H2,13,14,15)/b5-1+/t7-/m1/s1Names & synonyms
Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.
Classification & relationships
ChEBI ontologyRoles recorded in ChEBI
Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.
Mass ↔ amount of substance
Calculated from sourced massUses 250.191 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.
Elemental composition
Theoretical mass fractionsCOPNHCalculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.
Research & patent references
Selected source associationsSources & record history
Checked 27 Sep 2026Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0
PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.