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Chemical substance record

Etanidazole

22668-01-5C7H10N4O4214.181 g/mol
Organic/Inorganic Small MoleculeChEBI source record

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitro-1H-imidazol-1-yl)acetic acid with the amino group of ethanolamine. Used as a radiosensitising agent for hypoxic tumour cells. — ChEBI

Safety references

Safety documents & references

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Identity & molecular properties

Source-linked values
CAS number22668-01-5ChEBI ↗
Molecular formulaC7H10N4O4ChEBI ↗
Molar mass214.181 g/molChEBI ↗
Monoisotopic mass214.0702 DaChEBI ↗
Formal charge0ChEBI ↗
ChEBI identifierCHEBI:75473ChEBI ↗

Cross-source molecular data

PubChem
Molar mass214.18 g/molPubChem ↗
Exact mass214.07020481 DaPubChem ↗
Computed XLogP-1.3PubChem ↗
Topological polar surface area (Ų)113PubChem ↗
H-bond donors2PubChem ↗
H-bond acceptors5PubChem ↗
Rotatable bonds4PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

Copy any identifier
etanidazole
N-(2-hydroxyethyl)-2-(2-nitro-1H-imidazol-1-yl)acetamide
WCDWBPCFGJXFJZ-UHFFFAOYSA-N
O=C(Cn1ccnc1[N+](=O)[O-])NCCO
InChI=1S/C7H10N4O4/c12-4-2-8-6(13)5-10-3-1-9-7(10)11(14)15/h1,3,12H,2,4-5H2,(H,8,13)

Names & synonyms

N-(2-hydroxyethyl)-2-(2-nitro-1H-imidazol-1-yl)acetamide

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology
imidazolesChEBI parent class · 24780 ↗monocarboxylic acid amideChEBI parent class · 29347 ↗C-nitro compoundChEBI parent class · 35716 ↗
organic heterocyclic compoundorganic molecular entity

Roles recorded in ChEBI

radiosensitizing agentalkylating agentantineoplastic agentprodrug

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass
Equivalent amount
0.00466895 mol

Uses 214.181 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions
C
Carbon · 7 atoms
39.26%
O
Oxygen · 4 atoms
29.88%
N
Nitrogen · 4 atoms
26.16%
H
Hydrogen · 10 atoms
4.71%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations
Hypoxia and etanidazole alter radiation-induced apoptosis in HL60 cells but not in MOLT-4 cells. ↗International journal of radiation biology · 2002 Apr · PMID 12020438
PEG modulated release of etanidazole from implantable PLGA/PDLA discs. ↗Biomaterials · 2002 Sep · PMID 12109679
WO2011109387 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.
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Sources & record history

Checked 27 Sep 2026
EMBL-EBI ChEBI · CHEBI:75473

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

NCBI PubChem · CID 3276 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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