Chemical substance record

Droxidopa

23651-95-8C₉H₁₁NO₅213.189 g/mol

Organic/Inorganic Small MoleculeChEBI source record

A serine derivative that is L-serine substituted at the β-position by a 3,4-dihydroxyphenyl group. A prodrug for noradrenalone, it is used for treatment of neurogenic orthostatic hypotension — ChEBI

Safety references

Safety documents & references

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Identity & molecular properties

Source-linked values

CAS number	23651-95-8	ChEBI ↗
Molecular formula	C₉H₁₁NO₅	ChEBI ↗
Molar mass	213.189 g/mol	ChEBI ↗
Monoisotopic mass	213.06372 Da	ChEBI ↗
Formal charge	0	ChEBI ↗
ChEBI identifier	CHEBI:31524	ChEBI ↗

Cross-source molecular data

PubChem

Molar mass	213.19 g/mol	PubChem ↗
Exact mass	213.06372245 Da	PubChem ↗
Computed XLogP	-3.2	PubChem ↗
Topological polar surface area (Å²)	124	PubChem ↗
H-bond donors	5	PubChem ↗
H-bond acceptors	6	PubChem ↗
Rotatable bonds	3	PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

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Source preferred name

droxidopa

IUPAC name

(betaR)-beta,3-dihydroxy-L-tyrosine

InChIKey

QXWYKJLNLSIPIN-JGVFFNPUSA-N

SMILES

N[C@H](C(=O)O)[C@H](O)c1ccc(O)c(O)c1

InChI

InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1

Names & synonyms

(betaR)-beta,3-dihydroxy-L-tyrosineDopsdroxidopumNorthera

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

L-tyrosine derivativeChEBI parent class · 27177 ↗catecholsChEBI parent class · 33566 ↗

phenols organic molecular entity

Roles recorded in ChEBI

cardiovascular drugantihypertensive agentantiparkinson drugprodrugvasoconstrictor agent

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass

Amount

Input unit

Equivalent amount

0.00469067 mol

Uses 213.189 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions

C

Carbon · 9 atoms

50.71%

O

Oxygen · 5 atoms

37.52%

N

Nitrogen · 1 atom

6.57%

H

Hydrogen · 11 atoms

5.20%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations

L-threo-dihydroxyphenylserine (L-threo-DOPS; droxidopa) in the management of neurogenic orthostatic hypotension: a multi-national, multi-center, dose-ranging study in multiple system atrophy and pure autonomic failure. ↗Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2001 Aug · PMID 11710796

DBH deficiency in an elderly patient: efficacy and safety of chronic droxidopa. ↗Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2010 Jun · PMID 20063034

JP2005247828 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

NZ579368 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

US2008221170 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

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Sources & record history

Checked 27 Sep 2026

Identity, formula, mass, synonyms & ontologyEMBL-EBI ChEBI · CHEBI:31524

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

Additional molecular descriptorsNCBI PubChem · CID 92974 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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