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Chemical substance record

TDZD-8

327036-89-5C10H10N2O2S222.269 g/mol
Organic/Inorganic Small MoleculeChEBI source record

A member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a methyl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3β (GSK3β). An experimental compound which was being developed for the potential treatment of Alzheimer's disease. — ChEBI

Safety references

Safety documents & references

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Identity & molecular properties

Source-linked values
CAS number327036-89-5ChEBI ↗
Molecular formulaC10H10N2O2SChEBI ↗
Molar mass222.269 g/molChEBI ↗
Monoisotopic mass222.0463 DaChEBI ↗
Formal charge0ChEBI ↗
ChEBI identifierCHEBI:147411ChEBI ↗

Cross-source molecular data

PubChem
Molar mass222.27 g/molPubChem ↗
Exact mass222.04629874 DaPubChem ↗
Computed XLogP1.5PubChem ↗
Topological polar surface area (Ų)65.9PubChem ↗
H-bond donors0PubChem ↗
H-bond acceptors3PubChem ↗
Rotatable bonds2PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

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TDZD-8
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
JDSJDASOXWCHPN-UHFFFAOYSA-N
Cn1sc(=O)n(Cc2ccccc2)c1=O
InChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3

Names & synonyms

4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology
benzenesChEBI parent class · 22712 ↗thiadiazolidineChEBI parent class · 48865 ↗
organosulfur compoundorganic heterocyclic compoundorganic molecular entity

Roles recorded in ChEBI

antineoplastic agentneuroprotective agentanti-inflammatory agentapoptosis inducerEC 2.7.11.26 (tau-protein kinase) inhibitor

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass
Equivalent amount
0.00449905 mol

Uses 222.269 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions
C
Carbon · 10 atoms
54.04%
S
Sulfur · 1 atom
14.43%
O
Oxygen · 2 atoms
14.40%
N
Nitrogen · 2 atoms
12.60%
H
Hydrogen · 10 atoms
4.53%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations
First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. ↗Journal of medicinal chemistry · 2002 Mar 14 · PMID 11881998
Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8). ↗Blood · 2007 Dec 15 · PMID 17785584
NZ574619 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.
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Sources & record history

Checked 27 Sep 2026
EMBL-EBI ChEBI · CHEBI:147411

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

NCBI PubChem · CID 4124851 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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