Propane-1,2-diol
The simplest member of the class of propane-1,2-diols, consisting of propane in which a hydrogen at position 1 and a hydrogen at position 2 are substituted by hydroxy groups. A colourless, viscous, hygroscopic, low-melting (−59°C) and high-boiling (188°C) liquid with low toxicity, it is used as a solvent, emulsifying agent, and antifreeze. — ChEBI
Safety documents & references
1 indexed referencesFind a product-specific SDS
Safety guides and government classification records are not a manufacturer’s SDS. Match supplier, product number, concentration, physical form, region and revision before using a document.
Identity & molecular properties
Source-linked values| CAS number | 57-55-6 | ChEBI ↗ |
| Molecular formula | C3H8O2 | ChEBI ↗ |
| Molar mass | 76.095 g/mol | ChEBI ↗ |
| Monoisotopic mass | 76.05243 Da | ChEBI ↗ |
| Formal charge | 0 | ChEBI ↗ |
| ChEBI identifier | CHEBI:16997 | ChEBI ↗ |
Cross-source molecular data
PubChem| Molar mass | 76.09 g/mol | PubChem ↗ |
| Exact mass | 76.052429494 Da | PubChem ↗ |
| Computed XLogP | -0.9 | PubChem ↗ |
| Topological polar surface area (Ų) | 40.5 | PubChem ↗ |
| H-bond donors | 2 | PubChem ↗ |
| H-bond acceptors | 2 | PubChem ↗ |
| Rotatable bonds | 1 | PubChem ↗ |
PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.
Names & structural identifiers
Copy any identifierpropane-1,2-diolpropane-1,2-diolDNIAPMSPPWPWGF-UHFFFAOYSA-NCC(O)COInChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3Classification & relationships
ChEBI ontologyRoles recorded in ChEBI
Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.
Safety classification · Japan
NITE / Japanese governmentPropane-1,2-diol (Propylene glycol) · H30-A-003-METI, MOE
| Endpoint | Reported classification |
|---|---|
| Specific target organ toxicity - Single exposure | Category 1 (central nervous system, haemal system), Category 3 (narcotic effects) |
| Specific target organ toxicity - Repeated exposure | Category 1 (central nervous system, respiratory organs) |
Selected source-reported endpoints. Other endpoints, rationales and conditions remain in the original classification. Missing or unlisted information does not mean non-hazardous. This is not a global classification or transport decision.
Read the original NITE classificationMass ↔ amount of substance
Calculated from sourced massUses 76.095 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.
Elemental composition
Theoretical mass fractionsCOHCalculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.
Research & patent references
Selected source associationsSources & record history
Checked 27 Sep 2026Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0
PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.