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Chemical substance record

Linoleic acid

60-33-3C18H32O2280.452 g/mol
Organic/Inorganic Small MoleculeChEBI source record

An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry. — ChEBI

Safety references

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Identity & molecular properties

Source-linked values
CAS number60-33-3ChEBI ↗
Molecular formulaC18H32O2ChEBI ↗
Molar mass280.452 g/molChEBI ↗
Monoisotopic mass280.24023 DaChEBI ↗
Formal charge0ChEBI ↗
ChEBI identifierCHEBI:17351ChEBI ↗

Cross-source molecular data

PubChem
Molar mass280.4 g/molPubChem ↗
Exact mass280.240230259 DaPubChem ↗
Computed XLogP6.8PubChem ↗
Topological polar surface area (Ų)37.3PubChem ↗
H-bond donors1PubChem ↗
H-bond acceptors2PubChem ↗
Rotatable bonds14PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Molar masses differ between sources. Check isotope composition, source conventions and the original records before calculating a precise quantity.

Names & structural identifiers

Copy any identifier
linoleic acid
(9Z,12Z)-octadeca-9,12-dienoic acid
OYHQOLUKZRVURQ-HZJYTTRNSA-N
CCCCC/C=CC/C=CCCCCCCCC(=O)O
InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6-,10-9-

Names & synonyms

(9Z,12Z)-octadeca-9,12-dienoic acid

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology
octadecadienoic acidChEBI parent class · 25627 ↗omega-6 fatty acidChEBI parent class · 36009 ↗
carboxylic acidlipidorganic molecular entity

Roles recorded in ChEBI

hypoglycemic agentantineoplastic agentanti-asthmatic agentanti-obesity agentplant metaboliteDaphnia galeata metabolitealgal metabolite

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass
Equivalent amount
0.00356567 mol

Uses 280.452 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions
C
Carbon · 18 atoms
77.09%
H
Hydrogen · 32 atoms
11.50%
O
Oxygen · 2 atoms
11.41%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations
A role for linoleic acid in erythrocytes infected with Plasmodium berghei. ↗Biochimica et biophysica acta · 2000 Dec 15 · PMID 11113630
T cells ignore aniline, a prohapten, but respond to its reactive metabolites generated by phagocytes: possible implications for the pathogenesis of toxic oil syndrome. ↗Chemical research in toxicology · 2001 Apr · PMID 11304127
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Sources & record history

Checked 27 Sep 2026
EMBL-EBI ChEBI · CHEBI:17351

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

NCBI PubChem · CID 5280450 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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