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Chemical substance record

Tolbutamide

64-77-7C12H18N2O3S270.354 g/mol
Organic/Inorganic Small MoleculeChEBI source record

An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position. — ChEBI

Safety references

Safety documents & references

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Identity & molecular properties

Source-linked values
CAS number64-77-7ChEBI ↗
Molecular formulaC12H18N2O3SChEBI ↗
Molar mass270.354 g/molChEBI ↗
Monoisotopic mass270.10381 DaChEBI ↗
Formal charge0ChEBI ↗
ChEBI identifierCHEBI:27999ChEBI ↗

Cross-source molecular data

PubChem
Molar mass270.35 g/molPubChem ↗
Exact mass270.10381361 DaPubChem ↗
Computed XLogP2.3PubChem ↗
Topological polar surface area (Ų)83.7PubChem ↗
H-bond donors2PubChem ↗
H-bond acceptors3PubChem ↗
Rotatable bonds5PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

Copy any identifier
tolbutamide
N-[(butylamino)carbonyl]-4-methylbenzenesulfonamide
JLRGJRBPOGGCBT-UHFFFAOYSA-N
CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1
InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)

Names & synonyms

N-[(butylamino)carbonyl]-4-methylbenzenesulfonamidetolbutamidatolbutamidum

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology
N-sulfonylureaChEBI parent class · 76983 ↗
organosulfur compoundorganic molecular entity

Roles recorded in ChEBI

antiviral agentanalgesichypoglycemic agentantineoplastic agentpotassium channel blockerhuman metaboliteinsulin secretagogue

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass
Equivalent amount
0.00369885 mol

Uses 270.354 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions
C
Carbon · 12 atoms
53.31%
O
Oxygen · 3 atoms
17.75%
S
Sulfur · 1 atom
11.86%
N
Nitrogen · 2 atoms
10.36%
H
Hydrogen · 18 atoms
6.71%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations
Tolbutamide alters glucose transport and metabolism in the embryonic mouse heart. ↗Teratology · 2002 Jan · PMID 11835228
Platelet-derived growth factor-BB: a survival factor for the retinal microvasculature during periods of metabolic compromise. ↗Current eye research · 2001 Aug · PMID 11840346
DE1066575 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.
GB808071 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.
US2968158 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.
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Sources & record history

Checked 27 Sep 2026
EMBL-EBI ChEBI · CHEBI:27999

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

NCBI PubChem · CID 5505 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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