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Chemical substance record

Chloroform

67-66-3CHCl3119.378 g/mol

A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines. — ChEBI

Safety references

Safety documents & references

2 indexed references
US · NIOSH

Occupational chemical safety guide

Chloroform

Read official guide
JP · NITE

Government GHS classification

R03-C-059-MHLW · FY2021

View classification

Find a product-specific SDS

Safety guides and government classification records are not a manufacturer’s SDS. Match supplier, product number, concentration, physical form, region and revision before using a document.

Identity & molecular properties

Source-linked values
CAS number67-66-3ChEBI ↗
Molecular formulaCHCl3ChEBI ↗
Molar mass119.378 g/molChEBI ↗
Monoisotopic mass117.91438 DaChEBI ↗
Formal charge0ChEBI ↗
ChEBI identifierCHEBI:35255ChEBI ↗

Cross-source molecular data

PubChem
Molar mass119.37 g/molPubChem ↗
Exact mass117.914383 DaPubChem ↗
Computed XLogP2.3PubChem ↗
Topological polar surface area (Ų)0PubChem ↗
H-bond donors0PubChem ↗
H-bond acceptors0PubChem ↗
Rotatable bonds0PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

Copy any identifier
chloroform
chloroform
HEDRZPFGACZZDS-UHFFFAOYSA-N
[H]C(Cl)(Cl)Cl
InChI=1S/CHCl3/c2-1(3)4/h1H

Classification & relationships

ChEBI ontology

Roles recorded in ChEBI

central nervous system druginhalation anaestheticnon-polar solventcarcinogenic agentrefrigerant

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Safety classification · Japan

NITE / Japanese government
Japan · FY2021 source classification
Chloroform · R03-C-059-MHLW
EndpointReported classification
Acute toxicity (Oral)Category 4
Acute toxicity (Inhalation: Vapours)Category 3

Selected source-reported endpoints. Other endpoints, rationales and conditions remain in the original classification. Missing or unlisted information does not mean non-hazardous. This is not a global classification or transport decision.

Read the original NITE classification

Mass ↔ amount of substance

Calculated from sourced mass
Equivalent amount
0.00837675 mol

Uses 119.378 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions
Cl
Chlorine · 3 atoms
89.09%
C
Carbon · 1 atom
10.06%
H
Hydrogen · 1 atom
0.84%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations
Chloroform: An EPA test case. ↗Environmental health perspectives · 1999 Jul · PMID 10379014
Cytotoxicity evaluation of gutta-percha solvents: Chloroform and GP-Solvent (limonene). ↗Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics · 2004 Dec · PMID 15583552

Sources & record history

Checked 27 Sep 2026
EMBL-EBI ChEBI · CHEBI:35255

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

NCBI PubChem · CID 6212 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.