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Chemical substance record

Crisaborole

906673-24-3C14H10BNO3251.05 g/mol

A member of the class of benzoxaboroles that is 5-hydroxy-1,3-dihydro-2,1-benzoxaborole in which the phenolic hydrogen has been replaced by a 4-cyanophenyl group. A phosphodiesterase 4 inhibitor that is used for treatment of mild to moderate atopic dermatitis in children and adults. — ChEBI

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Identity & molecular properties

Source-linked values
CAS number906673-24-3ChEBI ↗
Molecular formulaC14H10BNO3ChEBI ↗
Molar mass251.05 g/molChEBI ↗
Monoisotopic mass251.07537 DaChEBI ↗
Formal charge0ChEBI ↗
ChEBI identifierCHEBI:134677ChEBI ↗

Cross-source molecular data

PubChem
Molar mass251.05 g/molPubChem ↗
Exact mass251.0753733 DaPubChem ↗
Topological polar surface area (Ų)62.5PubChem ↗
H-bond donors1PubChem ↗
H-bond acceptors4PubChem ↗
Rotatable bonds2PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

Copy any identifier
crisaborole
4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)oxy]benzonitrile
USZAGAREISWJDP-UHFFFAOYSA-N
N#Cc1ccc(Oc2ccc3c(c2)COB3O)cc1
InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2

Names & synonyms

4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)oxy]benzonitrileEucrisa

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

Roles recorded in ChEBI

non-steroidal anti-inflammatory drugdermatologic drugantipsoriaticphosphodiesterase IV inhibitor

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass
Equivalent amount
0.00398327 mol

Uses 251.05 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions
C
Carbon · 14 atoms
66.98%
O
Oxygen · 3 atoms
19.12%
N
Nitrogen · 1 atom
5.58%
B
Boron · 1 atom
4.31%
H
Hydrogen · 10 atoms
4.02%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations

Sources & record history

Checked 27 Sep 2026
EMBL-EBI ChEBI · CHEBI:134677

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

NCBI PubChem · CID 44591583 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.