Home/Chemicals/101975-10-4

Chemical substance record

Zardaverine

101975-10-4C₁₂H₁₀F₂N₂O₃268.219 g/mol

Organic/Inorganic Small MoleculeChEBI source record

A pyridazinone derivative in which pyridazin-3(2H)-one is substituted at C-6 with a 4-(difluoromethoxy)-3-methoxyphenyl group. It is a phosphodiesterase inhibitor, selective for PDE3 and 4. — ChEBI

Safety references

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Identity & molecular properties

Source-linked values

CAS number	101975-10-4	ChEBI ↗
Molecular formula	C₁₂H₁₀F₂N₂O₃	ChEBI ↗
Molar mass	268.219 g/mol	ChEBI ↗
Monoisotopic mass	268.06595 Da	ChEBI ↗
Formal charge	0	ChEBI ↗
ChEBI identifier	CHEBI:46548	ChEBI ↗

Cross-source molecular data

PubChem

Molar mass	268.22 g/mol	PubChem ↗
Exact mass	268.06594851 Da	PubChem ↗
Computed XLogP	2.2	PubChem ↗
Topological polar surface area (Å²)	59.9	PubChem ↗
H-bond donors	1	PubChem ↗
H-bond acceptors	6	PubChem ↗
Rotatable bonds	4	PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

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Source preferred name

zardaverine

IUPAC name

6-[4-(difluoromethoxy)-3-methoxyphenyl]pyridazin-3(2H)-one

InChIKey

HJMQDJPMQIHLPB-UHFFFAOYSA-N

SMILES

COc1cc(-c2ccc(=O)nn2)ccc1OC(F)F

InChI

InChI=1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17)

Names & synonyms

6-[4-(difluoromethoxy)-3-methoxyphenyl]pyridazin-3(2H)-onezardaverinazardaverinum

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

pyridazinoneChEBI parent class · 26414 ↗organofluorine compoundChEBI parent class · 37143 ↗

organofluorine compound organic heterocyclic compound organic molecular entity

Roles recorded in ChEBI

bronchodilator agentperipheral nervous system druganti-asthmatic drugEC 3.1.4.* (phosphoric diester hydrolase) inhibitor

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass

Amount

Input unit

Equivalent amount

0.0037283 mol

Uses 268.219 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions

C

Carbon · 12 atoms

53.74%

O

Oxygen · 3 atoms

17.89%

F

Fluorine · 2 atoms

14.17%

N

Nitrogen · 2 atoms

10.44%

H

Hydrogen · 10 atoms

3.76%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations

Crystal structure of phosphodiesterase 4D and inhibitor complex(1). ↗FEBS letters · 2002 Oct 23 · PMID 12387865

Zardaverine and aerosolised iloprost in a model of acute respiratory failure. ↗The European respiratory journal · 2003 Aug · PMID 12952271

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Sources & record history

Checked 27 Sep 2026

Identity, formula, mass, synonyms & ontologyEMBL-EBI ChEBI · CHEBI:46548

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

Additional molecular descriptorsNCBI PubChem · CID 5723 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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