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Chemical substance record

Methoxyflurane

76-38-0C3H4Cl2F2O164.966 g/mol
Organic/Inorganic Small MoleculeChEBI source record

An ether in which the two groups attached to the central oxygen atom are methyl and 2,2-dichloro-1,1-difluoroethyl. — ChEBI

Safety references

Safety documents & references

1 indexed references
US · NIOSH

Occupational chemical safety guide

Methoxyflurane

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Safety guides and government classification records are not a manufacturer’s SDS. Match supplier, product number, concentration, physical form, region and revision before using a document.

Identity & molecular properties

Source-linked values
CAS number76-38-0ChEBI ↗
Molecular formulaC3H4Cl2F2OChEBI ↗
Molar mass164.966 g/molChEBI ↗
Monoisotopic mass163.96073 DaChEBI ↗
Formal charge0ChEBI ↗
ChEBI identifierCHEBI:6843ChEBI ↗

Cross-source molecular data

PubChem
Molar mass164.96 g/molPubChem ↗
Exact mass163.9607265 DaPubChem ↗
Computed XLogP2.2PubChem ↗
Topological polar surface area (Ų)9.2PubChem ↗
H-bond donors0PubChem ↗
H-bond acceptors3PubChem ↗
Rotatable bonds2PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

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methoxyflurane
2,2-dichloro-1,1-difluoro-1-methoxyethane
RFKMCNOHBTXSMU-UHFFFAOYSA-N
COC(F)(F)C(Cl)Cl
InChI=1S/C3H4Cl2F2O/c1-8-3(6,7)2(4)5/h2H,1H3

Names & synonyms

2,2-dichloro-1,1-difluoro-1-methoxyethane2,2-dichloro-1,1-difluoroethyl methyl ethermethoxyfluranummetoxifluranoPenthrane

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology
etherChEBI parent class · 25698 ↗organochlorine compoundChEBI parent class · 36683 ↗organofluorine compoundChEBI parent class · 37143 ↗
etherorganofluorine compoundorganochlorine compoundorganic molecular entity

Roles recorded in ChEBI

analgesicnon-narcotic analgesicantineoplastic agentinhalation anaesthetichepatotoxic agentnephrotoxic agentvulnerary

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass
Equivalent amount
0.00606186 mol

Uses 164.966 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions
Cl
Chlorine · 2 atoms
42.98%
F
Fluorine · 2 atoms
23.03%
C
Carbon · 3 atoms
21.84%
O
Oxygen · 1 atom
9.70%
H
Hydrogen · 4 atoms
2.44%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations
Inhaled methoxyflurane and intranasal fentanyl for prehospital management of visceral pain in an Australian ambulance service. ↗Emergency medicine journal : EMJ · 2011 Jan · PMID 20466829
Effectiveness of morphine, fentanyl, and methoxyflurane in the prehospital setting. ↗Prehospital emergency care · 2010 Oct-Dec · PMID 20809687
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Sources & record history

Checked 27 Sep 2026
EMBL-EBI ChEBI · CHEBI:6843

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

NCBI PubChem · CID 4116 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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