Chemical substance record

Flufenamic acid

530-78-9C₁₄H₁₀F₃NO₂281.233 g/mol

Organic/Inorganic Small MoleculeChEBI source record

An aromatic amino acid consisting of anthranilic acid carrying an N-(trifluoromethyl)phenyl substituent. An analgesic and anti-inflammatory, it is used in rheumatic disorders. — ChEBI

Safety references

Safety documents & references

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Identity & molecular properties

Source-linked values

CAS number	530-78-9	ChEBI ↗
Molecular formula	C₁₄H₁₀F₃NO₂	ChEBI ↗
Molar mass	281.233 g/mol	ChEBI ↗
Monoisotopic mass	281.06636 Da	ChEBI ↗
Formal charge	0	ChEBI ↗
ChEBI identifier	CHEBI:42638	ChEBI ↗

Cross-source molecular data

PubChem

Molar mass	281.23 g/mol	PubChem ↗
Exact mass	281.06636305 Da	PubChem ↗
Computed XLogP	5.2	PubChem ↗
Topological polar surface area (Å²)	49.3	PubChem ↗
H-bond donors	2	PubChem ↗
H-bond acceptors	6	PubChem ↗
Rotatable bonds	3	PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

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Source preferred name

flufenamic acid

IUPAC name

2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid

InChIKey

LPEPZBJOKDYZAD-UHFFFAOYSA-N

SMILES

O=C(O)c1ccccc1Nc1cccc(C(F)(F)F)c1

InChI

InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20)

Names & synonyms

2-{[3-(trifluoromethyl)phenyl]amino}benzoic acidAchlessacide flufenamiqueacido flufenamicoacidum flufenamicum

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

aromatic amino acidChEBI parent class · 33856 ↗organofluorine compoundChEBI parent class · 37143 ↗

carboxylic acid amino acid organofluorine compound organic molecular entity

Roles recorded in ChEBI

non-steroidal anti-inflammatory drugnon-narcotic analgesicantipyreticEC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass

Amount

Input unit

Equivalent amount

0.00355577 mol

Uses 281.233 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions

C

Carbon · 14 atoms

59.79%

F

Fluorine · 3 atoms

20.27%

O

Oxygen · 2 atoms

11.38%

N

Nitrogen · 1 atom

4.98%

H

Hydrogen · 10 atoms

3.58%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations

Dose-dependent potentiation and inhibition of single Ca2+-activated K+ channels by flufenamic acid. ↗Membrane & cell biology · 2000 · PMID 11093589

Flufenamic acid is a pH-dependent antagonist of TRPM2 channels. ↗Neuropharmacology · 2004 Sep · PMID 15275834

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Sources & record history

Checked 27 Sep 2026

Identity, formula, mass, synonyms & ontologyEMBL-EBI ChEBI · CHEBI:42638

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

Additional molecular descriptorsNCBI PubChem · CID 3371 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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