Adefovir
A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection. — ChEBI
Safety documents & references
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Identity & molecular properties
Source-linked values| CAS number | 106941-25-7 | ChEBI ↗ |
| Molecular formula | C8H12N5O4P | ChEBI ↗ |
| Molar mass | 273.189 g/mol | ChEBI ↗ |
| Monoisotopic mass | 273.06269 Da | ChEBI ↗ |
| Formal charge | 0 | ChEBI ↗ |
| ChEBI identifier | CHEBI:2469 | ChEBI ↗ |
Cross-source molecular data
PubChem| Molar mass | 273.19 g/mol | PubChem ↗ |
| Exact mass | 273.06269088 Da | PubChem ↗ |
| Computed XLogP | -2 | PubChem ↗ |
| Topological polar surface area (Ų) | 136 | PubChem ↗ |
| H-bond donors | 3 | PubChem ↗ |
| H-bond acceptors | 8 | PubChem ↗ |
| Rotatable bonds | 5 | PubChem ↗ |
PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.
Names & structural identifiers
Copy any identifieradefovir{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonic acidSUPKOOSCJHTBAH-UHFFFAOYSA-NNc1ncnc2c1ncn2CCOCP(=O)(O)OInChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)Names & synonyms
Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.
Classification & relationships
ChEBI ontologyRoles recorded in ChEBI
Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.
Mass ↔ amount of substance
Calculated from sourced massUses 273.189 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.
Elemental composition
Theoretical mass fractionsCNOPHCalculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.
Research & patent references
Selected source associationsSources & record history
Checked 27 Sep 2026Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0
PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.