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Chemical substance record

Hydroxyurea

127-07-1CH4N2O276.055 g/mol

A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease. — ChEBI

Safety references

Safety documents & references

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Identity & molecular properties

Source-linked values
CAS number127-07-1ChEBI ↗
Molecular formulaCH4N2O2ChEBI ↗
Molar mass76.055 g/molChEBI ↗
Monoisotopic mass76.02728 DaChEBI ↗
Formal charge0ChEBI ↗
ChEBI identifierCHEBI:44423ChEBI ↗

Cross-source molecular data

PubChem
Molar mass76.055 g/molPubChem ↗
Exact mass76.027277375 DaPubChem ↗
Computed XLogP-1.8PubChem ↗
Topological polar surface area (Ų)75.4PubChem ↗
H-bond donors3PubChem ↗
H-bond acceptors2PubChem ↗
Rotatable bonds0PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

Copy any identifier
hydroxyurea
N-hydroxyurea
VSNHCAURESNICA-UHFFFAOYSA-N
NC(=O)NO
InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)

Names & synonyms

hidroxicarbamidahydroxycarbamidehydroxycarbamidumN-hydroxyurea

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

Roles recorded in ChEBI

antifibrotic agentantimetaboliteantineoplastic agentantihypertensive agentimmunosuppressive agentradical scavengerimmunomodulatorgenotoxinteratogenic agentDNA synthesis inhibitor

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass
Equivalent amount
0.0131484 mol

Uses 76.055 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions
O
Oxygen · 2 atoms
42.07%
N
Nitrogen · 2 atoms
36.83%
C
Carbon · 1 atom
15.79%
H
Hydrogen · 4 atoms
5.30%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations
Systematic review of combination antiretroviral therapy with didanosine plus hydroxyurea: a partial solution to Africa's HIV/AIDS problem? ↗International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2001 · PMID 11285159
Muco-cutaneous changes during long-term therapy with hydroxyurea in chronic myeloid leukaemia. ↗Clinical and experimental dermatology · 2001 Mar · PMID 11298103
US2705727 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

Sources & record history

Checked 27 Sep 2026
EMBL-EBI ChEBI · CHEBI:44423

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

NCBI PubChem · CID 3657 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.