Chemical substance record

Chlorphenamine

132-22-9C₁₆H₁₉ClN₂274.795 g/mol

Organic/Inorganic Small MoleculeChEBI source record

A tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma. — ChEBI

Safety references

Safety documents & references

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Identity & molecular properties

Source-linked values

CAS number	132-22-9	ChEBI ↗
Molecular formula	C₁₆H₁₉ClN₂	ChEBI ↗
Molar mass	274.795 g/mol	ChEBI ↗
Monoisotopic mass	274.12368 Da	ChEBI ↗
Formal charge	0	ChEBI ↗
ChEBI identifier	CHEBI:52010	ChEBI ↗

Cross-source molecular data

PubChem

Molar mass	274.79 g/mol	PubChem ↗
Exact mass	274.1236763 Da	PubChem ↗
Computed XLogP	3.4	PubChem ↗
Topological polar surface area (Å²)	16.1	PubChem ↗
H-bond donors	0	PubChem ↗
H-bond acceptors	2	PubChem ↗
Rotatable bonds	5	PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

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Source preferred name

chlorphenamine

IUPAC name

3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine

InChIKey

SOYKEARSMXGVTM-UHFFFAOYSA-N

SMILES

CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1

InChI

InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3

Names & synonyms

chlorphenaminumClofeniraminaclorfenaminaHaynon

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

pyridinesChEBI parent class · 26421 ↗tertiary amino compoundChEBI parent class · 50996 ↗monochlorobenzenesChEBI parent class · 83403 ↗

organochlorine compound organic heterocyclic compound organic molecular entity

Roles recorded in ChEBI

antidepressantH1-receptor antagonisthistamine antagonistanti-allergic agentserotonin uptake inhibitorantipruritic drug

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass

Amount

Input unit

Equivalent amount

0.00363908 mol

Uses 274.795 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions

C

Carbon · 16 atoms

69.94%

Cl

Chlorine · 1 atom

12.90%

N

Nitrogen · 2 atoms

10.19%

H

Hydrogen · 19 atoms

6.97%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations

Antihistamines versus aspirin for itching in late pregnancy. ↗The Cochrane database of systematic reviews · 2000 · PMID 10796091

Intestinal absorption and metabolism of chlorpheniramine enantiomers in rat. ↗Chirality · 2001 May 5 · PMID 11284026

US2567245 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

US2676964 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

US2766174 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

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Sources & record history

Checked 27 Sep 2026

Identity, formula, mass, synonyms & ontologyEMBL-EBI ChEBI · CHEBI:52010

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

Additional molecular descriptorsNCBI PubChem · CID 2725 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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