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Chemical substance record

Vorinostat

149647-78-9C14H20N2O3264.325 g/mol
Organic/Inorganic Small MoleculeChEBI source record

A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL). — ChEBI

Safety references

Safety documents & references

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Identity & molecular properties

Source-linked values
CAS number149647-78-9ChEBI ↗
Molecular formulaC14H20N2O3ChEBI ↗
Molar mass264.325 g/molChEBI ↗
Monoisotopic mass264.14739 DaChEBI ↗
Formal charge0ChEBI ↗
ChEBI identifierCHEBI:45716ChEBI ↗

Cross-source molecular data

PubChem
Molar mass264.32 g/molPubChem ↗
Exact mass264.14739250 DaPubChem ↗
Computed XLogP1.9PubChem ↗
Topological polar surface area (Ų)78.4PubChem ↗
H-bond donors3PubChem ↗
H-bond acceptors3PubChem ↗
Rotatable bonds8PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

Copy any identifier
vorinostat
N-hydroxy-N'-phenyloctanediamide
WAEXFXRVDQXREF-UHFFFAOYSA-N
O=C(CCCCCCC(=O)Nc1ccccc1)NO
InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)

Names & synonyms

N-hydroxy-N'-phenyloctanediamidevorinostatumZolinza

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology
hydroxamic acidChEBI parent class · 24650 ↗dicarboxylic acid diamideChEBI parent class · 35779 ↗
organic molecular entity

Roles recorded in ChEBI

antipsychotic agentantineoplastic agentEC 3.5.1.98 (histone deacetylase) inhibitoranti-HIV agentapoptosis induceranti-anaemic agent

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass
Equivalent amount
0.00378322 mol

Uses 264.325 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions
C
Carbon · 14 atoms
63.62%
O
Oxygen · 3 atoms
18.16%
N
Nitrogen · 2 atoms
10.60%
H
Hydrogen · 20 atoms
7.63%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations
Vorinostat induced cellular stress disrupts the p38 mitogen activated protein kinase and extracellular signal regulated kinase pathways leading to apoptosis in Waldenström macroglobulinemia cells. ↗Leukemia & lymphoma · 2011 Sep · PMID 21657958
A phase I trial of vorinostat and bortezomib in children with refractory or recurrent solid tumors: a Children's Oncology Group phase I consortium study (ADVL0916). ↗Pediatric blood & cancer · 2013 Mar · PMID 22887890
CN102641261 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.
KR20110045493 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.
NZ592686 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.
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Sources & record history

Checked 27 Sep 2026
EMBL-EBI ChEBI · CHEBI:45716

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

NCBI PubChem · CID 5311 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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