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Chemical substance record

Bufexamac

2438-72-4C12H17NO3223.272 g/mol
Organic/Inorganic Small MoleculeChEBI source record

A hydroxamic acid derived from phenylacetamide in which the benzene moiety is substituted at C-4 by a butoxy group. It has anti-inflammatory, analgesic, and antipyretic properties. — ChEBI

Safety references

Safety documents & references

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Identity & molecular properties

Source-linked values
CAS number2438-72-4ChEBI ↗
Molecular formulaC12H17NO3ChEBI ↗
Molar mass223.272 g/molChEBI ↗
Monoisotopic mass223.12084 DaChEBI ↗
Formal charge0ChEBI ↗
ChEBI identifierCHEBI:31317ChEBI ↗

Cross-source molecular data

PubChem
Molar mass223.27 g/molPubChem ↗
Exact mass223.12084340 DaPubChem ↗
Computed XLogP1.9PubChem ↗
Topological polar surface area (Ų)58.6PubChem ↗
H-bond donors2PubChem ↗
H-bond acceptors3PubChem ↗
Rotatable bonds6PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

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bufexamac
2-(4-butoxyphenyl)-N-hydroxyacetamide
MXJWRABVEGLYDG-UHFFFAOYSA-N
CCCCOc1ccc(CC(=O)NO)cc1
InChI=1S/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7,15H,2-3,8-9H2,1H3,(H,13,14)

Names & synonyms

2-(4-butoxyphenyl)-N-hydroxyacetamidebufexamacobufexamacum

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology
hydroxamic acidChEBI parent class · 24650 ↗aromatic etherChEBI parent class · 35618 ↗
etherorganic molecular entity

Roles recorded in ChEBI

non-steroidal anti-inflammatory drugnon-narcotic analgesicantipyretic

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass
Equivalent amount
0.00447884 mol

Uses 223.272 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions
C
Carbon · 12 atoms
64.55%
O
Oxygen · 3 atoms
21.50%
H
Hydrogen · 17 atoms
7.67%
N
Nitrogen · 1 atom
6.27%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations
[Severe allergic contact dermatitis with generalized spread due to bufexamac presenting as the "baboon" syndrome]. ↗Deutsche medizinische Wochenschrift (1946) · 2003 Mar 14 · PMID 12635026
Efficacy of bufexamac (NFN) cream in skin diseases. A double-blind multicentre trial. ↗Dermatologica · 1977 · PMID 140084
BE661226 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.
US3479396 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.
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Sources & record history

Checked 27 Sep 2026
EMBL-EBI ChEBI · CHEBI:31317

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

NCBI PubChem · CID 2466 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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