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Chemical substance record

Pomalidomide

19171-19-8C₁₃H₁₁N₃O₄273.248 g/mol

Organic/Inorganic Small MoleculeChEBI source record

An aromatic amine that is thalidomide substituted at position 4 on the isoindole ring system by an amino group. Used for the treatment of multiple myeloma in patients who failed to respond to previous therapies. — ChEBI

Safety references

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Identity & molecular properties

Source-linked values

CAS number	19171-19-8	ChEBI ↗
Molecular formula	C₁₃H₁₁N₃O₄	ChEBI ↗
Molar mass	273.248 g/mol	ChEBI ↗
Monoisotopic mass	273.07496 Da	ChEBI ↗
Formal charge	0	ChEBI ↗
ChEBI identifier	CHEBI:72690	ChEBI ↗

Cross-source molecular data

PubChem

Molar mass	273.24 g/mol	PubChem ↗
Exact mass	273.07495584 Da	PubChem ↗
Computed XLogP	0.2	PubChem ↗
Topological polar surface area (Å²)	110	PubChem ↗
H-bond donors	2	PubChem ↗
H-bond acceptors	5	PubChem ↗
Rotatable bonds	1	PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

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Source preferred name

pomalidomide

IUPAC name

4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione

InChIKey

UVSMNLNDYGZFPF-UHFFFAOYSA-N

SMILES

Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O

InChI

InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)

Names & synonyms

4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dionePomalyst

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

isoindolesChEBI parent class · 24897 ↗aromatic amineChEBI parent class · 33860 ↗dicarboximideChEBI parent class · 35356 ↗piperidonesChEBI parent class · 48589 ↗

organic heterocyclic compound organic molecular entity

Roles recorded in ChEBI

antifibrotic agentantineoplastic agentangiogenesis inhibitorimmunomodulatoranti-anaemic agent

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass

Amount

Input unit

Equivalent amount

0.00365968 mol

Uses 273.248 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions

C

Carbon · 13 atoms

57.14%

O

Oxygen · 4 atoms

23.42%

N

Nitrogen · 3 atoms

15.38%

H

Hydrogen · 11 atoms

4.06%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations

Long-term outcome of pomalidomide therapy in myelofibrosis. ↗American journal of hematology · 2012 Jan · PMID 22081489

Management of myeloproliferative neoplasms: from academic guidelines to clinical practice. ↗Current hematologic malignancy reports · 2012 Mar · PMID 22278747

US2007004920 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

US2007048327 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

US2007155791 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

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Sources & record history

Checked 27 Sep 2026

Identity, formula, mass, synonyms & ontologyEMBL-EBI ChEBI · CHEBI:72690

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

Additional molecular descriptorsNCBI PubChem · CID 134780 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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