Chemical substance record

Amiloride

2609-46-3C₆H₈ClN₇O229.631 g/mol

Organic/Inorganic Small MoleculeChEBI source record

A member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid. — ChEBI

Safety references

Safety documents & references

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Identity & molecular properties

Source-linked values

CAS number	2609-46-3	ChEBI ↗
Molecular formula	C₆H₈ClN₇O	ChEBI ↗
Molar mass	229.631 g/mol	ChEBI ↗
Monoisotopic mass	229.04789 Da	ChEBI ↗
Formal charge	0	ChEBI ↗
ChEBI identifier	CHEBI:2639	ChEBI ↗

Cross-source molecular data

PubChem

Molar mass	229.63 g/mol	PubChem ↗
Exact mass	229.0478856 Da	PubChem ↗
Computed XLogP	-0.7	PubChem ↗
Topological polar surface area (Å²)	159	PubChem ↗
H-bond donors	4	PubChem ↗
H-bond acceptors	5	PubChem ↗
Rotatable bonds	1	PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

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Source preferred name

amiloride

IUPAC name

3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide

InChIKey

XSDQTOBWRPYKKA-UHFFFAOYSA-N

SMILES

N=C(N)NC(=O)c1nc(Cl)c(N)nc1N

InChI

InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)

Names & synonyms

3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamideamiloridaamiloridum

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

guanidinesChEBI parent class · 24436 ↗aromatic amineChEBI parent class · 33860 ↗organochlorine compoundChEBI parent class · 36683 ↗pyrazinesChEBI parent class · 38314 ↗

organochlorine compound organic heterocyclic compound organic molecular entity

Roles recorded in ChEBI

diureticcardiovascular drugantihypertensive agentimmunosuppressive agentsodium channel blocker

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass

Amount

Input unit

Equivalent amount

0.00435481 mol

Uses 229.631 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions

N

Nitrogen · 7 atoms

42.70%

C

Carbon · 6 atoms

31.38%

Cl

Chlorine · 1 atom

15.44%

O

Oxygen · 1 atom

6.97%

H

Hydrogen · 8 atoms

3.51%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations

Regulation of epithelial sodium channel in puromycin aminonucleoside-induced unilateral experimental nephrotic syndrome in normal and analbuminemic Nagase rats. ↗Nephron. Physiology · 2005 · PMID 16020936

Epithelial sodium channel inhibition by amiloride on blood pressure and cardiovascular disease risk in young prehypertensives. ↗Journal of clinical hypertension (Greenwich, Conn.) · 2014 Jan · PMID 24410943

BE639386 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

US3313813 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

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Sources & record history

Checked 27 Sep 2026

Identity, formula, mass, synonyms & ontologyEMBL-EBI ChEBI · CHEBI:2639

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

Additional molecular descriptorsNCBI PubChem · CID 16231 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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