Chemical substance record

Ethosuximide

77-67-8C₇H₁₁NO₂141.17 g/mol

Organic/Inorganic Small MoleculeChEBI source record

A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures. — ChEBI

Safety references

Safety documents & references

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Identity & molecular properties

Source-linked values

CAS number	77-67-8	ChEBI ↗
Molecular formula	C₇H₁₁NO₂	ChEBI ↗
Molar mass	141.17 g/mol	ChEBI ↗
Monoisotopic mass	141.07898 Da	ChEBI ↗
Formal charge	0	ChEBI ↗
ChEBI identifier	CHEBI:4887	ChEBI ↗

Cross-source molecular data

PubChem

Molar mass	141.17 g/mol	PubChem ↗
Exact mass	141.078978594 Da	PubChem ↗
Computed XLogP	0.4	PubChem ↗
Topological polar surface area (Å²)	46.2	PubChem ↗
H-bond donors	1	PubChem ↗
H-bond acceptors	2	PubChem ↗
Rotatable bonds	1	PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

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Source preferred name

ethosuximide

IUPAC name

3-ethyl-3-methylpyrrolidine-2,5-dione

InChIKey

HAPOVYFOVVWLRS-UHFFFAOYSA-N

SMILES

CCC1(C)CC(=O)NC1=O

InChI

InChI=1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)

Names & synonyms

3-ethyl-3-methylpyrrolidine-2,5-dioneethosuximidumetosuximida

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

dicarboximideChEBI parent class · 35356 ↗pyrrolidinoneChEBI parent class · 38275 ↗

organic heterocyclic compound organic molecular entity

Roles recorded in ChEBI

geroprotectorT-type calcium channel blockerantidepressantanalgesicanticonvulsantantispasmodic drug

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass

Amount

Input unit

Equivalent amount

0.00708366 mol

Uses 141.17 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions

C

Carbon · 7 atoms

59.56%

O

Oxygen · 2 atoms

22.67%

N

Nitrogen · 1 atom

9.92%

H

Hydrogen · 11 atoms

7.85%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations

Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity. ↗Bioorganic & medicinal chemistry letters · 2003 Aug 18 · PMID 12873507

Effects of anticonvulsant drugs on life span. ↗Archives of neurology · 2006 Apr · PMID 16606760

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Sources & record history

Checked 27 Sep 2026

Identity, formula, mass, synonyms & ontologyEMBL-EBI ChEBI · CHEBI:4887

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

Additional molecular descriptorsNCBI PubChem · CID 3291 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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