Home/Chemicals/1982-37-2

Chemical substance record

Methdilazine

1982-37-2C₁₈H₂₀N₂S296.439 g/mol

Organic/Inorganic Small MoleculeChEBI source record

A phenothiazine substituted on nitrogen by a (1-methylpyrrolidin-3-yl)methyl group; a first-generation antihistamine with anticholinergic properties. — ChEBI

Safety references

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Identity & molecular properties

Source-linked values

CAS number	1982-37-2	ChEBI ↗
Molecular formula	C₁₈H₂₀N₂S	ChEBI ↗
Molar mass	296.439 g/mol	ChEBI ↗
Monoisotopic mass	296.13472 Da	ChEBI ↗
Formal charge	0	ChEBI ↗
ChEBI identifier	CHEBI:6823	ChEBI ↗

Cross-source molecular data

PubChem

Molar mass	296.4 g/mol	PubChem ↗
Exact mass	296.13471982 Da	PubChem ↗
Computed XLogP	5.2	PubChem ↗
Topological polar surface area (Å²)	31.8	PubChem ↗
H-bond donors	0	PubChem ↗
H-bond acceptors	3	PubChem ↗
Rotatable bonds	2	PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

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Source preferred name

methdilazine

IUPAC name

10-[(1-methylpyrrolidin-3-yl)methyl]-10H-phenothiazine

InChIKey

HTMIBDQKFHUPSX-UHFFFAOYSA-N

SMILES

CN1CCC(CN2c3ccccc3Sc3ccccc32)C1

InChI

InChI=1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3

Names & synonyms

10-[(1-methylpyrrolidin-3-yl)methyl]-10H-phenothiazineDilosynmetdilazinamethdilazinumTacarylTacazyl

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

phenothiazinesChEBI parent class · 38093 ↗N-alkylpyrrolidineChEBI parent class · 46775 ↗

organic heterocyclic compound organic molecular entity

Roles recorded in ChEBI

histamine antagonistcholinergic antagonistantipruritic drug

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass

Amount

Input unit

Equivalent amount

0.00337338 mol

Uses 296.439 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions

C

Carbon · 18 atoms

72.93%

S

Sulfur · 1 atom

10.82%

N

Nitrogen · 2 atoms

9.45%

H

Hydrogen · 20 atoms

6.80%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations

METHDILAZINE INTOXICATION. ↗The Journal of the Medical Society of New Jersey · 1963 Mar · PMID 14080889

Evaluation of methdilazine hydrochloride as an antipruritic agent. ↗North Carolina medical journal · 1960 May · PMID 14403486

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Sources & record history

Checked 27 Sep 2026

Identity, formula, mass, synonyms & ontologyEMBL-EBI ChEBI · CHEBI:6823

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

Additional molecular descriptorsNCBI PubChem · CID 14677 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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