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Chemical substance record

Thioridazine

50-52-2C21H26N2S2370.587 g/mol

A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position. — ChEBI

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Identity & molecular properties

Source-linked values
CAS number50-52-2ChEBI ↗
Molecular formulaC21H26N2S2ChEBI ↗
Molar mass370.587 g/molChEBI ↗
Monoisotopic mass370.15374 DaChEBI ↗
Formal charge0ChEBI ↗
ChEBI identifierCHEBI:9566ChEBI ↗

Cross-source molecular data

PubChem
Molar mass370.6 g/molPubChem ↗
Exact mass370.15374118 DaPubChem ↗
Computed XLogP5.9PubChem ↗
Topological polar surface area (Ų)57.1PubChem ↗
H-bond donors0PubChem ↗
H-bond acceptors4PubChem ↗
Rotatable bonds4PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

Copy any identifier
thioridazine
10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine
KLBQZWRITKRQQV-UHFFFAOYSA-N
CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2
InChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3

Names & synonyms

10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazineMallorolMallorylMelerilMellarilMellaril-SMelleretsMelleretteMellerilOrsanilSonapaxthioridazinum

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

Roles recorded in ChEBI

antidepressantanxiolytic drugantineoplastic agentalpha-adrenergic antagonistH1-receptor antagonistserotonergic antagonistdopaminergic antagonistfirst generation antipsychoticEC 3.4.21.26 (prolyl oligopeptidase) inhibitorEC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass
Equivalent amount
0.00269842 mol

Uses 370.587 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions
C
Carbon · 21 atoms
68.06%
S
Sulfur · 2 atoms
17.31%
N
Nitrogen · 2 atoms
7.56%
H
Hydrogen · 26 atoms
7.07%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations
Thioridazine for dementia. ↗The Cochrane database of systematic reviews · 2000 · PMID 10796547
Thioridazine for dementia. ↗The Cochrane database of systematic reviews · 2001 · PMID 11686961

Sources & record history

Checked 27 Sep 2026
EMBL-EBI ChEBI · CHEBI:9566

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

NCBI PubChem · CID 5452 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.