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Chemical substance record

Diflunisal

22494-42-4C13H8F2O3250.2 g/mol

An organofluorine compound comprising salicylic acid having a 2,4-difluorophenyl group at the 5-position. — ChEBI

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Identity & molecular properties

Source-linked values
CAS number22494-42-4ChEBI ↗
Molecular formulaC13H8F2O3ChEBI ↗
Molar mass250.2 g/molChEBI ↗
Monoisotopic mass250.04415 DaChEBI ↗
Formal charge0ChEBI ↗
ChEBI identifierCHEBI:39669ChEBI ↗

Cross-source molecular data

PubChem
Molar mass250.20 g/molPubChem ↗
Exact mass250.04415044 DaPubChem ↗
Computed XLogP4.4PubChem ↗
Topological polar surface area (Ų)57.5PubChem ↗
H-bond donors2PubChem ↗
H-bond acceptors5PubChem ↗
Rotatable bonds2PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

Copy any identifier
diflunisal
2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
HUPFGZXOMWLGNK-UHFFFAOYSA-N
O=C(O)c1cc(-c2ccc(F)cc2F)ccc1O
InChI=1S/C13H8F2O3/c14-8-2-3-9(11(15)6-8)7-1-4-12(16)10(5-7)13(17)18/h1-6,16H,(H,17,18)

Names & synonyms

2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

Roles recorded in ChEBI

non-steroidal anti-inflammatory druganalgesicnon-narcotic analgesichypoglycemic agentantirheumatic drug

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass
Equivalent amount
0.0039968 mol

Uses 250.2 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions
C
Carbon · 13 atoms
62.41%
O
Oxygen · 3 atoms
19.18%
F
Fluorine · 2 atoms
15.19%
H
Hydrogen · 8 atoms
3.22%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations
Sensitive and selective determination of diflunisal in human plasma by LC-MS. ↗Journal of chromatographic science · 2013 Oct · PMID 23144359
Human serum albumin-based design of a diflunisal prodrug. ↗European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2013 Aug · PMID 23416065

Sources & record history

Checked 27 Sep 2026
EMBL-EBI ChEBI · CHEBI:39669

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

NCBI PubChem · CID 3059 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.