Midodrine
An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective α-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine. — ChEBI
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Identity & molecular properties
Source-linked values| CAS number | 42794-76-3 | ChEBI ↗ |
| Molecular formula | C12H18N2O4 | ChEBI ↗ |
| Molar mass | 254.286 g/mol | ChEBI ↗ |
| Monoisotopic mass | 254.12666 Da | ChEBI ↗ |
| Formal charge | 0 | ChEBI ↗ |
| ChEBI identifier | CHEBI:6933 | ChEBI ↗ |
Cross-source molecular data
PubChem| Molar mass | 254.28 g/mol | PubChem ↗ |
| Exact mass | 254.12665706 Da | PubChem ↗ |
| Computed XLogP | -0.6 | PubChem ↗ |
| Topological polar surface area (Ų) | 93.8 | PubChem ↗ |
| H-bond donors | 3 | PubChem ↗ |
| H-bond acceptors | 5 | PubChem ↗ |
| Rotatable bonds | 6 | PubChem ↗ |
PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.
Names & structural identifiers
Copy any identifiermidodrinerac-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]glycinamidePTKSEFOSCHHMPD-UHFFFAOYSA-NCOc1ccc(OC)c(C(O)CNC(=O)CN)c1InChI=1S/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16)Names & synonyms
Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.
Classification & relationships
ChEBI ontologyRoles recorded in ChEBI
Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.
Mass ↔ amount of substance
Calculated from sourced massUses 254.286 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.
Elemental composition
Theoretical mass fractionsCONHCalculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.
Research & patent references
Selected source associationsSources & record history
Checked 27 Sep 2026Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0
PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.