Chemical substance record

Diazoxide

364-98-7C₈H₇ClN₂O₂S230.676 g/mol

Organic/Inorganic Small MoleculeChEBI source record

A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the β- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies. — ChEBI

Safety references

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Identity & molecular properties

Source-linked values

CAS number	364-98-7	ChEBI ↗
Molecular formula	C₈H₇ClN₂O₂S	ChEBI ↗
Molar mass	230.676 g/mol	ChEBI ↗
Monoisotopic mass	229.99168 Da	ChEBI ↗
Formal charge	0	ChEBI ↗
ChEBI identifier	CHEBI:4495	ChEBI ↗

Cross-source molecular data

PubChem

Molar mass	230.67 g/mol	PubChem ↗
Exact mass	229.9916763 Da	PubChem ↗
Computed XLogP	1.2	PubChem ↗
Topological polar surface area (Å²)	66.9	PubChem ↗
H-bond donors	1	PubChem ↗
H-bond acceptors	3	PubChem ↗
Rotatable bonds	0	PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

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Source preferred name

diazoxide

IUPAC name

7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

InChIKey

GDLBFKVLRPITMI-UHFFFAOYSA-N

SMILES

CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1

InChI

InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)

Names & synonyms

7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxidediazoxidodiazoxidumEudemine

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

sulfoneChEBI parent class · 35850 ↗organochlorine compoundChEBI parent class · 36683 ↗benzothiadiazineChEBI parent class · 50265 ↗

organosulfur compound organochlorine compound organic heterocyclic compound organic molecular entity

Roles recorded in ChEBI

antidepressantdiureticbeta-adrenergic agonistbronchodilator agentsympathomimetic agenthypoglycemic agentvasodilator agentantihypertensive agentcardiotonic drugsodium channel blocker

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass

Amount

Input unit

Equivalent amount

0.00433508 mol

Uses 230.676 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions

C

Carbon · 8 atoms

41.65%

Cl

Chlorine · 1 atom

15.37%

S

Sulfur · 1 atom

13.90%

O

Oxygen · 2 atoms

13.87%

N

Nitrogen · 2 atoms

12.14%

H

Hydrogen · 7 atoms

3.06%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations

Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetes. ↗Endocrinology · 2000 Oct · PMID 11014217

Chronic suppression of insulin by diazoxide alters the activities of key enzymes regulating hepatic gluconeogenesis in Zucker rats. ↗European journal of endocrinology · 2002 Jun · PMID 12039709

DE723278 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

US2986573 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

US3345365 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

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Sources & record history

Checked 27 Sep 2026

Identity, formula, mass, synonyms & ontologyEMBL-EBI ChEBI · CHEBI:4495

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

Additional molecular descriptorsNCBI PubChem · CID 3019 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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