Chemical substance record

Niclosamide

50-65-7C₁₃H₈Cl₂N₂O₄327.123 g/mol

Organic/Inorganic Small MoleculeChEBI source record

A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections. — ChEBI

Safety references

Safety documents & references

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Identity & molecular properties

Source-linked values

CAS number	50-65-7	ChEBI ↗
Molecular formula	C₁₃H₈Cl₂N₂O₄	ChEBI ↗
Molar mass	327.123 g/mol	ChEBI ↗
Monoisotopic mass	325.98611 Da	ChEBI ↗
Formal charge	0	ChEBI ↗
ChEBI identifier	CHEBI:7553	ChEBI ↗

Cross-source molecular data

PubChem

Molar mass	327.12 g/mol	PubChem ↗
Exact mass	325.9861121 Da	PubChem ↗
Computed XLogP	4	PubChem ↗
Topological polar surface area (Å²)	95.2	PubChem ↗
H-bond donors	2	PubChem ↗
H-bond acceptors	4	PubChem ↗
Rotatable bonds	2	PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

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Source preferred name

niclosamide

IUPAC name

5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide

InChIKey

RJMUSRYZPJIFPJ-UHFFFAOYSA-N

SMILES

O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1O

InChI

InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)

Names & synonyms

5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamideAtenaseBayluscideCestocidDeverminDevermineFedal-TelminFenasalHelmiantinIomesanLintexMansonil

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

secondary carboxamideChEBI parent class · 140325 ↗benzamidesChEBI parent class · 22702 ↗C-nitro compoundChEBI parent class · 35716 ↗salicylanilidesChEBI parent class · 53468 ↗monochlorobenzenesChEBI parent class · 83403 ↗

organochlorine compound organic molecular entity

Roles recorded in ChEBI

anticoronaviral agentpiscicideantiviral agentmolluscicideantiparasitic agentanthelminthic drughypoglycemic agentantirheumatic drugapoptosis inducerSTAT3 inhibitor

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass

Amount

Input unit

Equivalent amount

0.00305695 mol

Uses 327.123 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions

C

Carbon · 13 atoms

47.73%

Cl

Chlorine · 2 atoms

21.67%

O

Oxygen · 4 atoms

19.56%

N

Nitrogen · 2 atoms

8.56%

H

Hydrogen · 8 atoms

2.47%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations

Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ↗ACS medicinal chemistry letters · 2010 Dec 9 · PMID 24900231

[Study on the factors affecting the degradation of niclosamide in the soil]. ↗Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control · 2020 Nov 17 · PMID 33325188

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Sources & record history

Checked 27 Sep 2026

Identity, formula, mass, synonyms & ontologyEMBL-EBI ChEBI · CHEBI:7553

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

Additional molecular descriptorsNCBI PubChem · CID 4477 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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