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Chemical substance record

Mefenamic acid

61-68-7C15H15NO2241.29 g/mol

An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis. — ChEBI

Safety references

Safety documents & references

1 indexed references
JP · NITE

Government GHS classification

24A6028 · FY2012

View classification

Find a product-specific SDS

Safety guides and government classification records are not a manufacturer’s SDS. Match supplier, product number, concentration, physical form, region and revision before using a document.

Identity & molecular properties

Source-linked values
CAS number61-68-7ChEBI ↗
Molecular formulaC15H15NO2ChEBI ↗
Molar mass241.29 g/molChEBI ↗
Monoisotopic mass241.11028 DaChEBI ↗
Formal charge0ChEBI ↗
ChEBI identifierCHEBI:6717ChEBI ↗

Cross-source molecular data

PubChem
Molar mass241.28 g/molPubChem ↗
Exact mass241.110278721 DaPubChem ↗
Computed XLogP5.1PubChem ↗
Topological polar surface area (Ų)49.3PubChem ↗
H-bond donors2PubChem ↗
H-bond acceptors3PubChem ↗
Rotatable bonds3PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

Copy any identifier
mefenamic acid
2-[(2,3-dimethylphenyl)amino]benzoic acid
HYYBABOKPJLUIN-UHFFFAOYSA-N
Cc1cccc(Nc2ccccc2C(=O)O)c1C
InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18)

Names & synonyms

2-[(2,3-dimethylphenyl)amino]benzoic acidacide mefenamiqueacido mefenamicoacidum mefenamicumPonstel

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

Roles recorded in ChEBI

non-steroidal anti-inflammatory druganalgesicantipyretichypoglycemic agentEC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitorxenobioticantirheumatic drugenvironmental contaminant

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Safety classification · Japan

NITE / Japanese government
Japan · FY2012 source classification
Mefenamic acid · 24A6028
EndpointReported classification
Acute toxicity (Oral)Category 4
Reproductive toxicityCategory 2, Additional category: Effects on or via lactation
Specific target organ toxicity - Single exposureCategory 1 (digestive system, blood), Category 2 (nervous system)
Specific target organ toxicity - Repeated exposureCategory 1 (kidney, digestive system, blood)

Selected source-reported endpoints. Other endpoints, rationales and conditions remain in the original classification. Missing or unlisted information does not mean non-hazardous. This is not a global classification or transport decision.

Read the original NITE classification

Mass ↔ amount of substance

Calculated from sourced mass
Equivalent amount
0.00414439 mol

Uses 241.29 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions
C
Carbon · 15 atoms
74.67%
O
Oxygen · 2 atoms
13.26%
H
Hydrogen · 15 atoms
6.27%
N
Nitrogen · 1 atom
5.81%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations
Anti-inflammatory, antipyretic and antinociceptive properties of N-(2,3-xylyl)anthranilic acid (mefenamic acid). ↗The Journal of pharmacology and experimental therapeutics · 1962 Dec · PMID 14001132
[Mefenamic acid and other non-steroidal anti-inflammatory agents in dental practice. A review of the literature]. ↗Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia · 2007 · PMID 17330662
BE605302 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.
US3138636 · Patent reference ↗Patent cross-reference supplied by ChEBI. Association alone does not establish claim scope.

Sources & record history

Checked 27 Sep 2026
EMBL-EBI ChEBI · CHEBI:6717

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

NCBI PubChem · CID 4044 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.