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Chemical substance record

Roducitabine

865838-26-2C10H12FN3O4257.221 g/mol

A triol that is (1S,2R)-4-fluoro-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol which is substituted by a 4-amino-2-oxopyrimidin-1(2H)-yl group at position 5. It is a cytidine analog which exhibits anticancer activity in several cancers, including gemcitabine-resistant tumours. — ChEBI

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Safety documents & references

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Identity & molecular properties

Source-linked values
CAS number865838-26-2ChEBI ↗
Molecular formulaC10H12FN3O4ChEBI ↗
Molar mass257.221 g/molChEBI ↗
Monoisotopic mass257.08118 DaChEBI ↗
Formal charge0ChEBI ↗
ChEBI identifierCHEBI:147412ChEBI ↗

Cross-source molecular data

PubChem
Molar mass257.22 g/molPubChem ↗
Exact mass257.08118403 DaPubChem ↗
Computed XLogP-2.6PubChem ↗
Topological polar surface area (Ų)119PubChem ↗
H-bond donors4PubChem ↗
H-bond acceptors5PubChem ↗
Rotatable bonds2PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

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roducitabine
4-amino-1-[(1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)cyclopent-2-en-1-yl]pyrimidin-2(1H)-one
QLLGKCJUPWYJON-HLTSFMKQSA-N
Nc1ccn([C@@H]2C(F)=C(CO)[C@@H](O)[C@H]2O)c(=O)n1
InChI=1S/C10H12FN3O4/c11-6-4(3-15)8(16)9(17)7(6)14-2-1-5(12)13-10(14)18/h1-2,7-9,15-17H,3H2,(H2,12,13,18)/t7-,8-,9+/m1/s1

Names & synonyms

4-amino-1-[(1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)cyclopent-2-en-1-yl]pyrimidin-2(1H)-one

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

Roles recorded in ChEBI

antimetaboliteantineoplastic agentprodrugDNA synthesis inhibitorapoptosis inducer

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass
Equivalent amount
0.00388771 mol

Uses 257.221 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions
C
Carbon · 10 atoms
46.70%
O
Oxygen · 4 atoms
24.88%
N
Nitrogen · 3 atoms
16.34%
F
Fluorine · 1 atom
7.39%
H
Hydrogen · 12 atoms
4.70%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations

Sources & record history

Checked 27 Sep 2026
EMBL-EBI ChEBI · CHEBI:147412

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

NCBI PubChem · CID 11242315 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.