Chemical substance record

Antazoline

91-75-8C₁₇H₁₉N₃265.36 g/mol

Organic/Inorganic Small MoleculeChEBI source record

A member of the class of imidazolines that is 2-aminomethyl-2-imidazoline in which the exocyclic amino hydrogens are replaced by benzyl and phenyl groups. Antazoline is only found in individuals that have taken the drug. — ChEBI

Safety references

Safety documents & references

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Identity & molecular properties

Source-linked values

CAS number	91-75-8	ChEBI ↗
Molecular formula	C₁₇H₁₉N₃	ChEBI ↗
Molar mass	265.36 g/mol	ChEBI ↗
Monoisotopic mass	265.1579 Da	ChEBI ↗
Formal charge	0	ChEBI ↗
ChEBI identifier	CHEBI:84115	ChEBI ↗

Cross-source molecular data

PubChem

Molar mass	265.35 g/mol	PubChem ↗
Exact mass	265.157897619 Da	PubChem ↗
Computed XLogP	2.6	PubChem ↗
Topological polar surface area (Å²)	27.6	PubChem ↗
H-bond donors	1	PubChem ↗
H-bond acceptors	2	PubChem ↗
Rotatable bonds	5	PubChem ↗

PubChem computed values are shown separately from the ChEBI record. An exact InChIKey match was used to connect the records. Molecular descriptors do not describe a supplied product’s purity, particle size or performance.

Names & structural identifiers

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Source preferred name

antazoline

IUPAC name

N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline

InChIKey

REYFJDPCWQRWAA-UHFFFAOYSA-N

SMILES

c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1

InChI

InChI=1S/C17H19N3/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16/h1-10H,11-14H2,(H,18,19)

Names & synonyms

antazolinaantazolinumN-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline

Names are supplied by ChEBI. Trade names and related synonyms may describe a broader product context.

Classification & relationships

ChEBI ontology

aromatic amineChEBI parent class · 33860 ↗tertiary amino compoundChEBI parent class · 50996 ↗imidazolinesChEBI parent class · 53095 ↗

organic heterocyclic compound organic molecular entity

Roles recorded in ChEBI

xenobioticH1-receptor antagonistcholinergic antagonistnasal decongestant

Database role annotations describe reported biological or chemical roles; they are not product approvals or recommendations for use.

Mass ↔ amount of substance

Calculated from sourced mass

Amount

Input unit

Equivalent amount

0.00376847 mol

Uses 265.36 g/mol from ChEBI. Assumes the substance described by this record; no purity or concentration correction is applied.

Elemental composition

Theoretical mass fractions

C

Carbon · 17 atoms

76.95%

N

Nitrogen · 3 atoms

15.84%

H

Hydrogen · 19 atoms

7.22%

Calculated theoretical mass fractions from the reported formula and PubChem periodic-table atomic masses. These are not assay or purity results.

Research & patent references

Selected source associations

Antazoline-induced immune hemolytic anemia, hemoglobinuria, and acute renal failure. ↗Acta medica Scandinavica · 1975 Sep · PMID 1180129

A rapid derivative spectrophotometric method for simultaneous determination of naphazoline and antazoline in eye drops. ↗Chemical & pharmaceutical bulletin · 2006 Jan · PMID 16394564

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Sources & record history

Checked 27 Sep 2026

Identity, formula, mass, synonyms & ontologyEMBL-EBI ChEBI · CHEBI:84115

Release 255, 9 September 2026. ChEBI three-star (manually annotated) source entry. View original record ↗ · CC BY 4.0

Additional molecular descriptorsNCBI PubChem · CID 2200 · retrieved 2026-09-27

PubCAS formats source data, connects references and computes explicitly labelled conversions. CAS cross-references are supplied by ChEBI; they do not constitute CAS verification or endorsement.

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